- Simon Baker as Patrick Jane
- Robin Tunney as Teresa Lisbon
- Amanda Righetti as Grace Van Pelt
- Tim Kang as Kimball Cho
- Owain Yeoman as Wayne Rigsby
- Terry Kinney
- William Forsythe
- Ivan Sergei
Simon Baker as Patrick Jane, an independent consultant with the California Bureau of Investigation (CBI), who has a remarkable track record for solving serious crimes by using his razor sharp skills of observation. Within the Bureau, Jane is notorious for his blatant lack of protocol and his semi-celebrity past as a psychic medium, whose paranormal abilities he now admits he feigned. Jane's role in cracking a series of tough high-profile cases is greatly valued by his fellow agents.
However, no-nonsense Senior Agent Teresa Lisbon openly resists having Jane in her unit and alternates between reluctantly acknowledging Jane's usefulness and blasting him for his theatrics, narcissism and dangerous lack of boundaries. Lisbon's team includes agents Kimball Cho, Wayne Rigsby and rookie member Grace Van Pelt, who all think Jane's a loose cannon but admire his charm and knack for clearing cases.